January 24, 2019

Feeling groovy: Neurons integrate better with muscle grown on grooved platforms

  • By

Growing muscle tissue on grooved platforms helps neurons more effectively integrate with the muscle, a requirement for engineering muscle in the lab that responds and functions like muscle in the body, University of Illinois researchers found in a new study. Such engineered muscle with integrated nerves has applications in reconstructive and rehabilitative medicine, as well as for engineered biological machines or robots. “With this approach, we can engineer muscle outside of the body so it […]

M. Christina White, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign
January 10, 2019

Researchers diversify drug development options with new metal catalyst

  • By

A University of Illinois team of researchers led by chemistry professor and Carle Illinois research mentor M. Christina White has developed a new manganese-based catalyst that can change the structure of druglike molecules to make new drugs, advancing the pace and efficiency of drug development.

January 3, 2019

Unmuting large silent genes lets bacteria produce new molecules, potential drug candidates

  • By

By enticing away the repressors dampening unexpressed, silent genes in Streptomyces bacteria, researchers at the University of Illinois have unlocked several large gene clusters for new natural products, according to a study published in the journal Nature Chemical Biology. Since many antibiotics, anti-cancer agents and other drugs have been derived from genes readily expressed in Streptomyces, the researchers hope that unsilencing genes that have not previously been expressed in the lab will yield additional candidates […]

December 19, 2018

New drug seeks receptors in sarcoma cells, attacks tumors in animal trials

  • By

A new compound that targets a receptor within sarcoma cancer cells shrank tumors and hampered their ability to spread in mice and pigs, a study from researchers at the University of Illinois reports. The researchers conducted a multi-year, cross-disciplinary study that went from screening potential drug candidates to identifying and synthesizing one compound, to packaging it into nanoparticles for delivery in cells, to testing it in cell cultures and finally in mice and pigs with […]

Leanne Labriola, Dipanjan Pan, Ketan Dighe, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign
August 31, 2018

Color-changing sensor detects signs of eye damage in tears

  • By

Researchers developed a rapid sensing gel to measure a molecular marker of eye injury in a teardrop.

New CRSPR Technique, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign
August 16, 2018

New CRISPR technique skips over portions of genes that can cause disease

  • By

In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell’s internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building. This gives researchers a way not only to eliminate a mutated gene sequence, but to influence how the gene is expressed and regulated. Such targeted editing could one day be useful for treating genetic diseases caused […]

August 2, 2018

Nowhere to hide: Molecular probe illuminates elusive cancer stem cells in live mice

  • By

University of Illinois researchers developed a molecular probe that can tag and track elusive cancer stem cells in both cell cultures and live organisms.

Ruby Mendenhall, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign
August 2, 2018

Ruby Mendenhall and Interdisciplinary Research

  • By

Ask Ruby Mendenhall about the scope of her activities, and you’re quickly overwhelmed. Ask her to illustrate how they all connect, and you’ll soon have a page full of circles, lines, themes and projects – many of them connecting people you’d think would have little to talk about. Yet they do.

Timothy Fan, University of Illinois at Urbana-Champaign, Carle Illinois College of Medicine
July 12, 2018

Products of omega-3 fatty acid metabolism may have anticancer effects, study shows

  • By

A class of molecules formed when the body metabolizes omega-3 fatty acids could inhibit cancer’s growth and spread, University of Illinois researchers report in a new study in mice. The molecules, called endocannabinoids, are made naturally by the body and have similar properties to cannabinoids found in marijuana – but without the psychotropic effects. In mice with tumors of osteosarcoma – a bone cancer that is notoriously painful and difficult to treat – endocannabinoids slowed […]

First Class, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign
July 3, 2018

Carle Illinois Welcomes Inaugural Class

  • By

The Carle Illinois College of Medicine, the world’s first engineering-based medical school, welcomed its first class of 32 students July 2. A partnership between the University of Illinois at Urbana-Champaign and the Carle Health System, the college aims to create a cohort of physician-innovators who exemplify the qualities of compassion, competence, curiosity and creativity. The students will receive full four-year tuition scholarships, privately funded, valued at more than $200,000 each. “We are so excited to […]