University of Illinois at Urbana-Champaign
Carle Illinois College of Medicine

Gustavo Caetano-Anolles

Gustavo Caetano-Anolles
Gustavo Caetano-Anolles
Professor
Biomedical and Translational Sciences
(217) 333-8172
332 National Soybean Res Ctr

For More Information

Resident Instruction

  • CPSC 567 / IB 505: BIOINFORMATICS AND SYSTEMS BIOLOGY
  • CPSC 569 / ANSC 542: APPLIED BIOINFORMATICS

Research Interests

  • Interaction of plants and microbes
  • The spontaneous mutation process
  • Evolution of biological networks
  • Function and structure in proteins and ncRNA
  • Evolution of macromolecular structure

Books Authored or Co-Authored (Original Editions)

  • Caetano-Anolles G and PM Gresshoff (1997) DNA markers: Protocols, Applications and Overviews. John Wiley & Sons, Inc., New York.
  • Caetano-Anolles G (2010) Evolutionary Genomics and Systems Biology. Wiley-Blackwell (ad).
  • Caetano-Anolles G (2021) Untangling Molecular Biodiversity. World Scientific (ad).

Selected Articles in Journals

  • Aziz MF, F Mughal, G Caetano-Anolles (2023) Tracing the birth of structural domains from loops during protein evolution. Scientific Reports 13(1): 14688 (full text)
  • Caetano-Anolles G, JM Claverie, A Nasir (2023) A critical analysis of the current state of virus taxonomy. Frontiers in Microbiology 14: 1240993 (full text)
  • Caetano-Anolles G (2023) Agency in evolution of biomolecular communication. Annals of the New York Academy of Sciences 1525(1): 88-103 (full text)
  • Hernandez N, G Caetano-Anolles (2023) Worldwide correlations support COVID-19 seasonal behavior and impact of global change. Evolutionary Bioinformatics 19: 11769343231169377 (full text)
  • Tomaszewski T, MA Ali, K Caetano-Anolles, G Caetano-Anolles (2023) Seasonal effects decouple SARS-CoV-2 haplotypes worldwide. F1000Research 12: 267 (full text) Press release: SARS-CoV-2 seasonal behavior traced back to genetics and global change
  • Caetano-Anolles G, MF Aziz, F Mughal, I Koc, K Caetano-Anolles, D Caetano-Anolles (2022) Recruitment: A problem of entangled temporal parts. Frontiers in Bioscience (Landmark Edition) 27(4):128 (full text)
  • Caetano-Anolles G, MF Aziz, F Mughal F, D Caetano-Anolles (2021) Tracing protein and proteome history with chronologies and networks: folding recapitulates evolution. Expert Review of Proteomics 18(10): 863-880 (full text)
  • Caetano-Anolles G (2021) The compressed vocabulary of microbial life. Frontiers in Microbiology 12: 655990 (full text)
  • Aziz MF, G Caetano-Anolles (2021) Evolution of networks of protein domain organization. Scientific Reports 11(1): 12075. (full text) Press release: Protein big bang reveals molecular makeup for medicine and bioengineering
  • Sun F, G Caetano-Anolles (2021) Menzerath-Altmann's law of syntax in RNA accretion history. Life (Basel) 11(6): 489 (full text)
  • Burra P, K Soto-Diaz, I Chalen, RJ Gonzalez-Ricon, D Istanto, G Caetano-Anolles (2021) Temperature and latitude correlate with SARS-CoV-2 epidemiological variables but not with genomic change worldwide. Evolutionary Bioinformatics 17: 1176934321989695 (full text) Press release: Global analysis suggests COVID-19 is seasonal
  • Tomaszewski T, RS DeVries, M Dong, G Bhatia, MD Nosworthy, X Zheng, G Caetano-Anolles (2020) New pathways of mutational change in SARS-CoV-2 proteomes involve regions of intrinsic disorder important for virus replication and release. Evolutionary Bioinformatics 16: 1-18 (full text) Press release: Illinois study tracks evolution of SARS-CoV-2 virus mutations
  • Mughal F, A Nasir, G Caetano-Anolles (2020) The origin and evolution of viruses inferred from fold family structure. Archives of Virology 165(10): 2177-2191 (full text)
  • Bokhari RH, N Amirjan, H Jeong, KM Kim, G Caetano-Anolles, A Nasir (2020) Bacterial origin and reductive evolution of the CPR group. Genome Biology and Evolution 12(3): 103-121 (abstract)
  • Santiago TR, CA Lopes, G Caetano-Anolles, ESG Mizubuti (2020) Genetic structure of Ralstonia solanacearum and Ralstonia pseudosolanacearum in Brazil. Plant Disease 104(4): 1019-1025 (abstract)
  • Mughal F, G Caetano-Anolles (2019) MANET 3.0: Hierarchy and modularity in evolving metabolic networks. PLoS ONE 14(10): e0224201 (abstract) Press release: Tracking metabolic history
  • Caetano-Anolles G, F Aziz, F Mughal, F Graeter, I Koc, K Caetano-Anolles, D Caetano-Anolles (2019) Emergence of hierarchical modularity in evolving networks uncovered by phylogenomic analysis. Evolutionary Bioinformatics 15: 1176934319872980 (abstract)
  • Jeong H, B Arif, G Caetano-Anolles, KM Kim, A Nasir (2019) Horizontal gene transfer in human-associated microorganisms inferred by phylogenetic reconstruction and reconciliation. Scientific Reports 9(1): 12173 (abstract) Press release: Horizontal gene transfer in the microbiome
  • Caetano-Anolles G, A Nasir, KM Kim, D Caetano-Anolles (2018) Rooting phylogenies and the Tree of Life while minimizing ad hoc and auxiliary assumptions. Evolutionary Bioinformatics 14: 1176934318805101 (abstract)
  • Koc I, I Yuksel, G Caetano-Anolles G (2018) Metabolite-centric reporter pathway and tripartite network analysis of Arabidopsis under cold stress. Frontiers in Bioengineering and Biotechnology 6: 121 (abstract) Press release: Whole system view of plant cold stress
  • Koc I, G Caetano-Anolles (2017) A natural history of molecular functions inferred from an extensive phylogenomic analysis of Gene Ontology data. PLoS ONE 12(5): e0176129 (abstract) Press release: History of molecular functions
  • Malik SS, S Azem-e-Zhara, KM Kim, G Caetano-Anolles, A Nasir (2017) Do viruses exchange genes across superkingdoms of life? Frontiers in Microbiology 8: 2110 (abstract) Press release: Viruses share genes across life
  • Aziz MF, K Caetano-Anolles, G Caetano-Anolles (2016) The early history and emergence of molecular functions and modular scale-free network behavior. Scientific Reports 6: 25058 (abstract)
  • Caetano-Anolles D, G Caetano-Anolles (2016) Piecemeal buildup of the genetic code, ribosomes, and genomes from primordial tRNA building blocks. Life 6: 43 (abstract)
  • Nasir A, G Caetano-Anolles (2015) A phylogenomic data-driven exploration of viral origins and evolution. Science Advances 1: e1500527 (abstract) Press release: Viruses are alive
  • Caetano-Anolles G, D Caetano-Anolles (2015) Computing the origin and evolution of the ribosome from its structure – Uncovering processes of macromolecular accretion benefitting synthetic biology. Computational and Structural Biotechnology Journal 13: 427-447 (abstract)
  • Caetano-Anolles G, M Wang, D Caetano-Anolles (2013) Structural phylogenomics retrodicts the origin of the genetic code and uncovers the evolutionary impact of protein flexibility. PLoS ONE 8(8): e72225 (abstract) Press release: Insights onto the origin of the genetic code
  • Debes C, M Wang, G Caetano-Anolles, F Graeter (2013) Folding rate evolution of protein domain structure. PLoS Computational Biology 9: e1002861 (abstract) Press release: Protein folds unravel origins of life
  • Nasir A, KM Kim, G Caetano-Anolles (2012) Giant viruses coexisted with cellular ancestors and represent a distinct supergroup along with superkingdoms Archaea, Bacteria and Eukarya. BMC Evolutionary Biology 15: 156 (abstract) Press release: Shaking up the tree of life
  • Mittenthal JE, D Caetano-Anolles, G Caetano-Anolles (2012) Biphasic patterns of diversification and the emergence of modules. Frontiers in Genetics 3: 147 (abstract)
  • Harish A, G Caetano-Anolles (2012) Ribosomal history reveals the origin of modern protein synthesis. PLoS ONE 7: e32776 (abstract) Press release: Challenging of the RNA world hypothesis
  • Kim KM, T Qin, Y-Y Jiang, L-L Chen, M Xiong, D Caetano-Anolles, H-Y Zhang, G Caetano-Anolles (2012) Protein domain structure uncovers the origin of aerobic metabolism and the rise of planetary oxygenation. Structure 20: 67-76 (abstract) Press release: Researchers identify molecular culprit in rise of planetary oxygen
  • Wang M, CG Kurland, G Caetano-Anolles (2011) Reductive evolution of proteomes and protein structures. Proceedings of the National Academy of Sciences USA 108: 11954-11958 (abstract) (pdf)
  • Wang M, YY Jiang, KM Kim, G Qu, HF Ji, JE Mittenthal, HY Zhang, G Caetano-Anolles (2011) A universal molecular clock of protein folds and its power in tracing the early history of aerobic metabolism and planet oxygenation. Molecular Biology and Evolution 28: 567-582 (abstract)
  • Sun F-J, G Caetano-Anolles (2010) The ancient history of the structure of ribonuclease P and the early origins of Archaea. BMC Bioinformatics 11:153 (abstract)
  • Dupont CL, A Butcher, RE Valas, PE Bourne, G Caetano-Anolles (2010) History of biological metal utilization inferred through phylogenomic analysis of protein structure. Proceedings of the National Academy of Sciences USA 107 (23): 10567-10572 (abstract)
  • Caetano-Anolles D, KM Kim, Caetano-Anolles (2010) Proteome evolution and the metabolic origins of translation and cellular life. Journal of Molecular Evolution 72: 14-32 (abstract)
  • Caetano-Anolles G, M Wang, D Caetano-Anolles, JE Mittenthal (2009) The origin, evolution and structure of the protein world. Biochemical Journal 417: 621-637 (abstract)(pdf).
  • Wang M, G Caetano-Anolles (2009) The evolutionary mechanics of domain organization in proteomes and the rise of modularity in the protein world. Structure 17: 66-78 (abstract) Press release: Study of protein structures reveals key events in evolutionary history
  • Sun F-J, G Caetano-Anolles (2008) Evolutionary patterns in the sequence and structure of transfer RNA: a window into early translation and the genetic code. PLoS ONE 3: e2799 (abstract)(pdf) Press release: Study reveals surprising details of the evolution of protein translation
  • Sun F-J, G Caetano-Anolles (2008) Evolutionary patterns in the sequence and structure of transfer RNA: early origins of Archaea and viruses. PLoS Computational Biology 4: e1000018. (abstract) (pdf) Press release: Researchers see history of life in the structure of transfer RNA
  • Wang M, LS Yafremava, D Caetano-Anolles, JE Mittenthal, G Caetano-Anolles (2007) Reductive evolution of architectural repertoires in proteomes and the birth of the tripartite world. Genome Research 17: 1572-1585 (abstract)
  • Caetano-Anolles G, HS Kim, JE Mittenthal (2007) The origin of modern metabolic networks inferred from phylogenomic analysis of protein architecture. Proceedings of the National Academy of Sciences USA 104: 9358-9363 (abstract)

Presentations

  • Caetano-Anollés G (2011) The phylogenomic roots of modern bochemistry. Molecular Frontiers Symposium, The Royal Swedish Academy of Sciences. May 23-25, 2011. Video presentation (video)
  • Caetano-Anollés G (2011) The phylogenomic roots of modern bochemistry. Paleobiology during the genomic era. Meeting sponsored by NASA and the Craig Venter Institute, May 12, 2011. Video presentation (video)

Recent Courses Taught

  • ANSC 542 (IB 506, CPSC 569) - Applied Bioinformatics
  • CPSC 294 - On-Campus Crop Sci Internship
  • CPSC 295 - Undergrad Research or Thesis
  • CPSC 567 (IB 505) - Bioinformatics & Systems Biol
  • CPSC 599 - Thesis Research