University of Illinois at Urbana-Champaign
Carle Illinois College of Medicine
Jodi A Flaws
Jodi A Flaws
Professor
Biomedical and Translational Sciences

Education

  • BS., St. Xavier University
  • MS., Loyola University
  • PhD., University of Arizona

Research Interests

  • The main focus of the Flaws lab is to determine the genetic and environmental factors that affect the female reproductive system. Specifically, the research in my laboratory is designed to address the following major questions: (1) Which genes and hormones regulate the normal development and function of the ovary? (2) What are the effects of environmental toxicants on the development and function of the ovary? (3) What are the mechanisms that underlie the effects of reproductive toxicants on the ovary? (4) Are environmental exposures associated with reproductive abnormalities in women?

Selected Articles in Journals

  • Hannon P.R., Peretz J.R., Flaws, J.A. (2014) Daily exposure to di(2-ethylhexyl) phthalate alters estrous cyclicity and accelerates primordial follicle recruitment potentially via dysregulation of the phosphatidylinositol 3-kinase signaling pathway in adult mice. Biology of Reproduction 90:136. PMID: 24804967.
  • Peretz, J., Vrooman, L., Ricke, W.A., Hunt, P.A., Ehrlich, S., Hauser, R., Padmanabhan, V., Taylor, H., Swan, S.H., VandeVoort, C., Flaws, J.A. (2014) Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence. Environmental Health Perspectives 122:775-86. PMID: 24896072.
  • Wang W., Hafner K., Flaws J.A. (2014) In utero bisphenol A exposure disrupts germ cell nest breakdown and reduces fertility with age in the mouse. Toxicology and Applied Pharmacology 276:157-64. PMID: 24576723
  • Craig, Z.R., Hannon, P., Wang, W., Ziv-Gal, A., Flaws, J.A. (2013) Di-n-butyl phthalate disrupts the expression of genes involved in cell cycle and apoptotic pathways in mouse ovarian antral follicles. Biology of Reproduction 81(1). PMID:23242528
  • Ziv-Gal, A., Craig, Z.R., Wang, W., Flaws, J.A. (2013) Bisphenol A inhibits cultured mouse ovarian follicle growth partially via the aryl hydrocarbon receptor signaling pathway. Reproductive Toxicology42C:58-67. PMID: 23928317
  • Craig, Z.R., Hannon, P., Flaws, J.A. (2013) Pregnenolone co-treatment partially restores steroidogenesis, but does not prevent growth inhibition and increased atresia in mouse ovarian antral follicles treated with mono-hydroxy methoxychlor. Toxicology Applied Pharmacology (Epub ahead of print). PMID: 23948739
  • Peretz, J., Flaws, J.A. (2013) Bisphenol A down-regulates rate-limiting Cyp11a1 to acutely inhibit steroidogenesis in cultured mouse antral follicles. Toxicology Applied Pharmacology 27:249-56. PMID: 23707772
  • Wang, W., Craig, Z.R., Basavarajappa, M.S., Hafner, K.S., Flaws, J.A. (2012) Mono(2-ethylhexyl) phthalate induces oxidative stress and inhibits growth of mouse ovarian antral follicles. Biology of Reproduction 87(6).PMID:23077170
  • Wang, W., Craig, Z.R., Basavarajappa, M.S., Gupta, R., Flaws, J.A. (2012) Di(2-ethylhexyl) phthalate inhibits growth of ovarian antral follicles through an oxidative stress pathway. Toxicology and Applied Pharmacology 258:288-295. PMID: 22155089
  • Ziv-Gal, A., Gallicchio, L., Miller, S.R., Zacur, H.A., Flaws, J.A. (2012) Genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway as potential risk factors for menopausal hot flashes. American Journal of Obstetrics and Gynecology 207:202. PMID:22840970
  • Selected from 170 manuscripts

Honors

  • Fellow of the Academy of Toxicological Sciences, 2013-current
  • Pfizer Animal Health Award for Research Excellence, 2009
  • University Scholar, 2009-2012

Recent Courses Taught

  • CB 516 (ENVS 516) - Reprod & Dev Toxicology
  • CB 552 - Ethics in Toxicology
  • CB 554 - Systems Toxicology
  • CB 596 (ENVS 596, PATH 596) - Interdisciplinary Tox Sem
  • NUTR 550 (FSHN 550) - Grantsmanship and Ethics
  • VM 602 - Structure and Function I