Manuel Enrique Hernandez

Course Director, Musculoskeletal
Carle Illinois College of Medicine

Teaching Associate Professor
Biomedical and Translational Sciences

For More Information

Biography

Manuel Hernandez received his Ph.D. from the University of Michigan at Ann Arbor in 2012. He is a teaching associate professor in Department of Biomedical and Translational Sciences at the at the Carle Illinois College of Medicine at the University of Illinois Urbana-Champaign, and affiliate faculty member in Bioengineering, the Beckman Institute, Health & Kinesiology, and Neuroscience Program. His fields of professional interest include aging, movement disorders, and systems neuroscience.

Resident Instruction

BSE 635: Musculoskeletal and Integumentary SP 2020-2024

Course Development

Spring 2019-2022 Course Co-Director for Carle Illinois College of Medicine BSE 635: Musculoskeletal and Integumentary
Spring 2017 and Spring 2019 Instructor for KIN 199: Undergraduate Open Seminar: Reimagining the future of brain injury treatment
Spring 2017 and Fall 2019 Instructor for KIN 199: Undergraduate Open Seminar: Baby boomers: A challenge to public health
Spring 2016 Instructor for KIN 494: Special Topics: Occupational & Rehabilitation Biomechanics
2015-2017 Instructor for KIN 494: Special Topics: Neuromechanics

Research Statement

Dr. Hernandez's research has focused on the use of experimental and theoretical models of risk factors for injury or disability during the performance of goal-directed movements in older adults with and without neurological disorders, particularly multiple sclerosis and Parkinson's disease. Dr. Hernandez is interested in the behavioral and neural mechanisms underlying postural dysfunction in older adults and particularly in the development of behavioral and neural biomarkers for early detection of neurological disorders.

Selected Articles in Journals

Jan, Y-K., Hu, Lung, C-W, Liau, B-Y., & Hernandez, M. E. Editorial for the Special Issue on Sensors and Wearable Technologies in Sports Biomechanics. Sensors, 24(19), 6219; https://doi.org/10.3390/s24196219.
Cerna, J., Gupta, P., He, M., Ziegelman, L., Hu, Y., & Hernandez, M. E. Tai-Chi Buffers Aging Effects in Functional Brain Connectivity. Brain Sciences, 14(9), 901; https://doi.org/10.3390/brainsci14090901.
Holtzer, R, Foley, F. W., Motl, R. W., Wagshul, M., Hernandez, M. E., Lipton, M. L., & Izzetoglu, M. (2024). Brain Hemodynamic Responses and Fall Prediction in Older Adults with Multiple Sclerosis. Multiple Sclerosis Journal; https://doi.org/10.1177/13524585241277400.
Bishnoi, A., Hu, Y., & Hernandez, M. E. (2024). Perturbation walking effects on prefrontal cortical activation and walking performance in older women with and without osteoarthritis. Frontiers in Aging Neuroscience; 16 - 2024, https://doi.org/10.3389/fnagi.2024.1403185.
Lin, C. F., Liau, J. C., Hernandez, M. E., Sadruddin, R., Pappu, S., & Jan, Y. K. (2024). Comparison of isometric and dynamic bridging exercise on low back muscle oxygenation in healthy adult. International Journal of Sports Medicine; https://doi.org/10.1055/a-2376-6255.
Hu, Y., Huang, M., Cerna, J., Kaur, R., & Hernandez, M. E. (2024) Tai Chi Expertise Classification in Older Adults Using Wrist Wearables and Machine Learning. Sensors, 24, 4955. https://doi.org/10.3390/s24154955.
Lin, S., Sun, P., Huang, L., Hernandez, M. E., Yu, H., & Jan, Y. K. (2024). Effects of the intensity, duration and muscle mass factors of isometric exercise on acute local muscle hemodynamic responses and systematic blood pressure regulation. Frontiers in Bioengineering and Biotechnology, 12:1444598, https://doi.org/10.3389/fbioe.2024.1444598.
Hernandez, M. E., Motl, R. W., Foley, F. Picone, M., Izzetoglu, M., Lipton, M. L., Wagshul, M., & Holtzer, R. (2024). Disability Moderates Dual Task Walking Performance and Neural Efficiency in Older Adults with Multiple Sclerosis. Neurorehabilitation & Neural Repair; https://doi.org/10.1177/15459683241273411.
Adamson, B. C., Lindsay, K., Almasri, L., Koppele-Duffy, M., Kirkpatrick, S., & Hernandez, M. E. (2024). Evaluating the Impact of Seated Pilates on Functional Outcomes Among Those with Mild, Moderate, and Severe MS Impairment: A Pilot Feasibility Trial. Adapted Physical Activity Quarterly; https://doi.org/10.1123/apaq.2023-0159.
Holtzer, R., Motl, R. W., Wagshul, M., Picone, M., Hernandez, M. E., Izzetoglu, M., Lipton, M. L., & Foley, F. (2024). Life Space Assessment and Falls in Older Adults with Multiple Sclerosis. Multiple sclerosis and related disorders, 105671, https://doi.org/10.1016/j.msard.2024.105671.
Mo, P. C., Lin, C. F., Li, Y., Liau, J. C., Hernandez, M. E., Hung, I. Y. J., & Jan, Y. K. (2024). Application of near-infrared spectroscopy to assess the effect of the cupping size on the spatial hemodynamic response from the area inside and outside the cup of the biceps. PLOS One, 19(5), e0302828, https://doi.org/10.1371/journal.pone.0302828.
Choi, S., Seo, JY, Hernandez, M. E., & Kitsiou, S. (2024). Conversational Agents in mHealth: Use Patterns, Challenges, and Design Opportunities for Individuals with Visual Impairments. Journal of Technology in Behavioral Science; https://doi.org/10.1007/s41347-024-00409-7.
Holtzer, R, Choi, J., Motl, R. W., Foley, F. W., Wagshul, M., Hernandez, M. E., Lipton, M. L., & Izzetoglu, M. (2024). Brain control of dual-task walking can be improved in aging and neurological disease. GeroScience; https://doi.org/10.1007/s11357-023-01054-3.
Motl, R. W., Choi, J., Foley, F. W., Picone, M. A., Lipton, M. L., Izzetoglu, M., Hernandez, M. E., Wagshul, M., & Holtzer, R. (2024). Initial Validation of the University of Alabama Birmingham Study of Aging Life-Space Assessment in Older Adults with Multiple Sclerosis. Multiple Sclerosis and Related Disorders; 82, 105354. https://doi.org/10.1016/j.msard.2023.105354.
Singh, M., Prakash, P., Kaur, R., Sowers, R., Brašić, J. R., & Hernandez, M. E. (2023). A Deep Learning Approach for Automatic and Objective Grading of Motor Impairment Severity in Parkinson’s Disease for use in Tele-Assessments. Sensors; 23, 9004. https://doi.org/10.3390/s23219004
Ziegelman, L., Kosuri, T., Hakim, H., Elshourbagy, A., Mills, K. A., Harrigan, T. P., Hernandez, M. E., & Brašić, J. R. (2023). Dataset of quality assurance measurements of rhythmic movements. Data in brief; 50, 109556. https://doi.org/10.1016/j.dib.2023.109556
Liau, B. Y., Lung, C. W., Hernandez, M. E., Mo, P. C., Li, Y., Guo, J., & Jan, Y. K. (2023). Using cross-correlation analysis of multi-channel near infrared spectroscopy to assess the hemodynamic response to cupping therapy. Biomedical Optics Express; 14(9), 4455-4467. https://doi.org/10.1364/BOE.493897
Elshourbagy, A., Eltaras, M. M., Abdalshafy, H., P., Javed, S., Sadaney, A. O., Harrigan, T. P., Mills, K. A., Hernandez, M. E. & Brašić, J. R. (2023). Feasibility of virtual low-cost continuous measurement of movements in the extremities of people with Parkinson’s disease. MethodsX; 11. https://doi.org/10.1016/j.mex.2023.102230
Li, Y., Mo, P. C., Lin, C. F., Pauly, S., Kundal, N., Hernandez, M.E. & Jan, Y. K. (2023). Using Near-Infrared Spectroscopy to Investigate the Effects of Pressures and Durations of Cupping Therapy on Muscle Blood Volume and Oxygenation. Journal of Biophotonics; https://doi.org/10.1002/jbio.202200342.
Hu, Y., Petruzzello, S. J., & Hernandez, M. E. (2023). Beta cortical oscillatory activities and their relationship to postural control in a standing balance demanding test: Influence of aging. Frontiers in Aging Neuroscience; 15:1126002. https://doi.org/10.3389/fnagi.2023.1126002.
Holtzer, R., Choi, J., Wagshul, M. E., Motl, R. W., Foley, F. W., Picone, M. A., Lipton, M. L., Izzetoglu, M., Hernandez, M. E., & Wagshul, M. (2023). Individual Reserve in Aging and Neurological Disease. Journal of Neurology; https://doi.org/10.1007/s00415-023-11656-8
Wagshul, M. E., Foley, F., Chaudhary, K., Lipton, M. L., Motl, R. W., Izzetoglu, M., Hernandez, M. E., Picone, M. A., & Holtzer, R. (2023). Differential Associations of Mobility with Fronto-Striatal Integrity and Lesion Load in Older Adults with and without Multiple Sclerosis. Neurorehabilitation and Neural Repair; 37(4), 205-217. https://doi.org/ 10.1177/15459683231164787
Kaur, R., Levy, J., Motl, R. W., Sowers, R., & Hernandez, M. E. (2023). Deep Learning for Multiple Sclerosis Differentiation Using Multi-Stride Dynamics in Gait. IEEE Transactions on Biomedical Engineering; https://doi.org/10.1109/TBME.2023.3238680
Kaur, R., Motl, R. W., Sowers, R., & Hernandez, M. E. (2023). A Vision-Based Gait Analysis Framework for Predicting Multiple Sclerosis and Parkinson’s Disease Gait Dysfunctions - A Deep Learning Approach. IEEE Journal of Biomedical and Health Informatics; 27(1), 190-201. https://doi.org/10.1109/JBHI.2022.3208077
Bishnoi, A., Shankar, M., Lee, R., Hu, Y., & Hernandez, M. E. (2022). Effects of therapeutic intervention on spatiotemporal gait parameters in adults with and without neurological disorder: systematic review and meta-analysis. Archives of Physical Medicine & Rehabilitation; https://doi.org/10.1016/j.apmr.2022.06.003
Hernandez, M. E., Ziegelman, L., Kosuri, T., Hakim, H., Zhao, L., Mills, K.A., & Brasic, J. (2022). Classification of extremity movements by visual observation of signals and their transforms. MethodsX. https://doi.org/10.1016/j.mex.2022.101739
Bishnoi, A., Lee, R., Hu, Y., Mahoney, J. R., & Hernandez, M. E. (2022). Effect of treadmill interventions on spatiotemporal gait parameters in adults with neurological disorders: Systematic Review and Meta-analysis of Randomized Controlled Trials. Int. J. Environ. Res. Public Health, 19, 2824. https://doi.org/10.3390/ijerph19052824
Meade, Z., Likens, A., Kent, J. A., Takahashi, K. Z., Wurdeman, S. R., Jacobsen, A. L., Hernandez, M. E., & Stergiou, N. (2022). Subthreshold vibration influences standing balance but has unclear impact on somatosensation in persons with transtibial amputations. Frontiers in Physiology. https://doi.org/10.3389/fphys.2022.810079
Bishnoi, A., Chaparro, G., & Hernandez, M. E. (2022). Effect of Heart Rate Reserve on Prefrontal Cortical Activation while dual-task walking in older adults. Int. J. Environ. Res. Public Health, 19, 47. https://doi.org/10.3390/ijerph19010047
Kaur, R., Chen, Z., Motl, R., Hernandez, M. E., & Sowers, R. (2021). Predicting Multiple Sclerosis from Gait Dynamics Using an Instrumented Treadmill - A Machine Learning Approach. IEEE Transactions on Biomedical Engineering, 68(9), 2666-2677. https://doi.org/10.1109/TBME.2020.3048142
Bishnoi, A., Holtzer, R., & Hernandez, M. E. (2021). Brain activation changes while walking in adults with and without neurological disease: Systematic Review and Meta-analysis of Functional Near-Infrared Spectroscopy. Brain Sciences, 11, 291. https://doi.org/10.3390/brainsci11030291
Hu, Y., Kattan, C., Kontos, D., Zhu, W., & Hernandez, M. E. (2021). Benefit of Tai Chi Quan Practice on Neuromuscular Functions in Older Adults. A Systematic Review and Meta-analysis. Complementary Therapies in Clinical Practice, 42, 101295. https://doi.org/10.1016/j.ctcp.2020.101295
Zanotto, T., Hernandez, M. E., Medrano, C. N., Wilund, K. R., & Sosnoff, J. J. (2020). Cardiac autonomic dysfunction and falls in people with multiple sclerosis: is there a link? An Opinion Article. Frontiers in Neuroscience, 14, 1299. https://doi.org/10.3389/fnins.2020.610917
Bishnoi, A., & Hernandez, M. E. (2020). Dual task walking costs in older adults with mild cognitive impairment: a systematic review and meta-analysis. Aging & Mental Health, 1-12. https://doi.org/10.1080/13607863.2020.1802576
Hernandez, M. E., Holtzer, R., Chaparro, G., Jean, K., Balto, J. M., Sandroff, B. M., Izzetoglu, M., & Motl, R. W. (2016). Brain activation changes during locomotion in middle-aged to older adults with multiple sclerosis. Journal of the Neurological Sciences, 370, 277-283. https://doi.org/10.1016/j.jns.2016.10.002
Moon, Y., Sung, J., An, R., Hernandez, M. E., & Sosnoff, J. J. (2016). Gait Variability in People with Neurological Disorders: A Systematic Review and Meta-analysis. Human Movement Science, 47, 197-208. https://doi.org/10.1016/j.humov.2016.03.010
Lainscsek, C., Hernandez, M. E., Weyhenmeyer, J., Sejnowski, T. J., & Poizner, H. (2013). Non-linear dynamical analysis of EEG time series distinguishes patients with Parkinson’s disease from healthy individuals. Frontiers in Neurology, 4, 200. https://doi.org/10.3389/fneur.2013.00200
Lukos, J. R., Snider, J., Hernandez, M. E., Tunik, E., Hillyard, S., & Poizner, H. (2013). Parkinson’s disease patients show impaired corrective response control and eye-hand coupling when reaching to virtual objects. Neuroscience, 254, 205-21. https://doi.org/10.1016/j.neuroscience.2013.09.026

Articles in Conference Proceedings

He, M., Cerna, J., Alkurdi, A., Dogan, A., Zhao, J., Clore, J., Sowers, R., Hsiao-Wecksler, H. T., & Hernandez, M. E. (2024). Physical, Social and Cognitive Stressor Identification using Electrocardiography-derived Features and Machine Learning from a Wearable Device. Proceedings of the 2024 of the IEEE-Engineering in Medicine and Biology Society (EMBC) International Conference; (In press).
Ziegelman, L., & Hernandez, M. E. (2024). Application of a Neural ODE to Classify Motion Control Strategy using EEG. Proceedings of the 2024 of the IEEE-Engineering in Medicine and Biology Society (EMBC) International Conference; (In press).
Sasso, G., Mou, L., & Hernandez, M. E. (2023). Classification of fall risk across the lifespan using gait derived features from a wearable device. Proceedings of the 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC); 2023, 1-4. https://doi.org/10.1109/EMBC40787.2023.10340146.
Prakash, P., Kaur, R., Levy, J., Sowers, R., Brasic, J., & Hernandez, M. E. (2023). A Deep Learning Approach for Grading of Motor Impairment Severity in Parkinson’s Disease. Proceedings of the 2023 45th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC); 2023, 1-4. https:/doi.org/10.1109/EMBC40787.2023.10341122.
Liao, G., Wang, S., Wei, Z., Liu, B., Okubo, R., & Hernandez, M. E. (2022). Online classifier of AMICA model to evaluate state anxiety while standing in virtual reality. Proceedings of the 2022 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2022, 381-384. https://doi.org/10.1109/EMBC48229.2022.9871843.
Ziegelman, L., Alkurdi, A., Hu, Y., Bishnoi, A., Kaur, R., Sowers, R., Hsiao-Wecksler, E. T., & Hernandez, M. E. (2021). Feasibility of VR Technology in Eliciting State Anxiety Changes While Walking in Older Women. Proceedings of the 2021 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2021, 583-586. https://doi.org/10.1109/EMBC46164.2021.9630542
Wang, S., Okubo, R., Liao, G., Ku, C., Sowers, R., & Hernandez, M. E. (2021). Designing a closed loop system to achieve real-time evaluation and manipulation of state anxiety while walking in virtual reality. Proceedings of the 2021 10th International IEEE/EMBS Conference on Neural Engineering (NER), 2021, 45-48. https://doi.org/10.1109/NER49283.2021.9441253
Weyhenmeyer, J., Hernandez, M. E., Lainscsek, C., Poizner, H., & Sejnowski, T. (2020). Multimodal classification of Parkinson’s disease using delay differential analysis. Proceedings of the 2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2020, 2868-2875. https://doi.org/10.1109/BIBM49941.2020.9313394
Sun, R., Kaur, R., Ziegelman, L., Yang, S., Sowers, R., & Hernandez, M. E. (2019). Using virtual reality to examine the correlation between balance function and anxiety in stance. Proceedings of the 2019 IEEE International Conference on Bioinformatics and Biomedicine (BIBM), 2019, 1633-1640. https://doi.org/10.1109/BIBM47256.2019.8983331
Kaur, R., Sun, R., Ziegelman, L., Sowers, R., & Hernandez, M. E. (2019). Using virtual reality to examine the neural and physiological anxiety-related responses to balance-demanding target-reaching leaning tasks. Proceedings of the 2019 IEEE-RAS International Conference on Humanoid Robots (HUMANOIDS), 2019, 1-7. https://doi.org/10.1109/Humanoids43949.2019.9035020
Kaur, R., Sun, R., Ziegelman, L., Sowers, R., & Hernandez, M. E. (2019). Using virtual reality to examine the neural and physiological responses to height and perturbations in quiet standing. Proceedings of the 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2019, 5233-5236. https://doi.org/10.1109/EMBC.2019.8857647