Health Innovation Professor Wawrzyniec L. Dobrucki
Wawrzyniec L. Dobrucki
Health Innovation Professor, Biomedical and Translational Sciences
(217) 244-3938
dobrucki@illinois.edu
4261 Beckman Institute
Molecular imaging | PET-CT | SPECT-CT | Optical imaging | Cardiovascular imaging | Angiogenesis | HFPEF | The receptor for advanced glycation end-products (RAGE)
Projects Available for Carle Illinois College of Medicine Student Participation
List of Projects - Our research group focuses on two primary areas of investigation: cardiovascular and cancer imaging, using multimodal approaches that combine various imaging and non-imaging technologies. In the field of cardiovascular imaging, we specialize in developing innovative imaging strategies to monitor therapeutic angiogenesis. To accomplish this, we employ novel multimodal probes, such as multimeric RGD-containing peptide constructs. Additionally, we evaluate the effectiveness of new therapies, including nanoparticle drug-delivery systems and transplanted cell homing and survival, using reporter gene imaging techniques. Our research integrates molecular imaging with imaging physiology, such as perfusion and hypoxia, as well as anatomy.
Hedhli J, Kim M, Knox HJ, Cole JA, Huynh T, Schuelke M, Dobrucki IT, Kalinowski L, Chan J, Sinusas AJ, Insana MF, Dobrucki LW. Imaging the Landmarks of Vascular Recovery. Theranostics. 2020 Jan 1;10(4):1733-1745. doi: 10.7150/thno.36022. PMID: 32042333; PMCID: PMC6993245.
In cancer imaging, we utilize quantitative PET-optical imaging to assess the expression of the receptor for advanced glycation end-products (RAGE). Our aim is to identify early markers of the transition from indolent to aggressive cancer. We also investigate the impact of diet on cancer initiation and progression, and evaluate the effectiveness of anti-RAGE therapies in prostate and breast cancers. To accomplish this, we employ a combination of imaging techniques that assess molecular events, physiology, and metabolism.
Konopka CJ, Woźniak M, Hedhli J, Siekierzycka A, Skokowski J, Pęksa R, Matuszewski M, Munirathinam G, Kajdacsy-Balla A, Dobrucki IT, Kalinowski L, Dobrucki LW. Quantitative imaging of the receptor for advanced glycation end-products in prostate cancer. Eur J Nucl Med Mol Imaging. 2020 Oct;47(11):2562-2576. doi: 10.1007/s00259-020-04721-1. Epub 2020 Mar 12. PMID: 32166512.
Why I'm Motivated to be a HIP Faculty Member:
In my role as a Health Innovation Professor, I serve as a bridge between physicians and academic researchers working at the intersection of medicine, basic science, and engineering. As the co-director of Phase 1 Cardio block and through my ongoing commitment to service at the Carle Illinois College of Medicine, I am dedicated to integrating engineering fundamentals into medical education. Specifically, I am directing efforts to provide students with hands-on experience in preclinical imaging and laboratory techniques, which are crucial for their development as well-rounded physicians and scientists. My goal is to equip students with the skills and knowledge they need to innovate and improve health care through the application of cutting-edge technology and interdisciplinary collaboration.
Carle Illinois College of Medicine Related Research
The combination of various imaging modalities and technologies has immense potential to transform the diagnosis and treatment of pathophysiological disorders at the cellular and organ level. This, in turn, can significantly reduce the social and economic costs associated with managing diseases. In the Experimental Molecular Imaging Laboratory (EMIL), my research focuses on developing integrated imaging approaches to enable personalized disease prevention through advanced diagnosis, risk stratification, and targeted cell therapies, leading to more efficient healthcare.
Professor Dobrucki's research interests involve creating novel, non-invasive targeted multimodal imaging strategies to assess tissue microenvironments and various biological processes in vivo. Specifically, he investigates therapeutic neovascularization, atherosclerosis, neoplastic progression, and cancer response to experimental therapies. By leveraging these cutting-edge technologies, we can more effectively monitor disease progression and assess the efficacy of different therapies, ultimately improving patient outcomes. Professor Dobrucki's work aims to contribute to a better understanding of disease pathogenesis and to support the development of novel therapeutic strategies tailored to individual patients.